Cisplatin pharmacology

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August undefined, 2024

WebJul 17, 2024 · Cisplatin is a widely used chemotherapeutic agent that is clinically approved to fight both carcinomas and sarcomas. It has relatively high efficiency in treating ovarian cancers and metastatic testicular cancers. It is generally accepted that the major mechanism of cisplatin anti-cancer action is DNA damage. WebCisplatin is an intercalating agent that induces apoptosis of cancer cells, and it has been the most widely used drug in the first-line chemotherapy. However, the increase in …

Exploring the Metabolic Differences between Cisplatin

WebSep 1, 2024 · Cisplatin for injection, USP, a platinum-based drug for intravenous use, is a white to light yellow lyophilized powder. Each vial of Cisplatin for injection, USP … WebI am a PhD student in the Department of Pharmacology and Experimental Therapeutics at Boston University Division of Graduate Medical Sciences. ... They also offer hope that cisplatin and ... great family vacation destinations in the us

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WebNov 7, 2024 · Patients with high-grade serous ovarian cancer (HGSC) frequently receive platinum-based chemotherapeutics, such as cisplatin. Cisplatin binds to DNA and induces DNA-damage culminating in mitochondria-mediated apoptosis. Interestingly, mitochondrial DNA is critically affected by cisplatin but its rel … WebTherapeutic efficacy of cisplatin-based treatment of late stage urothelial carcinoma (UC) is limited by chemoresistance. To elucidate underlying mechanisms and to develop new approaches for overcoming resistance, we generated long-term cisplatin treated (LTT) UC cell lines, characterised their cisplatin response, and determined the expression of … WebAbstract Platinum compounds represent a pharmacological class, essential for the treatment of some cancer diseases. The three molecules, cisplatin, carboplatin, and oxaliplatin, share some physiochemical and pharmacological properties, in particular the ability to … flir tg165 ir thermometer

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[Potentiation and mechanism of cisplatin-induced apoptosis by …

WebFeb 17, 2024 · Cisplatin infusion solutions at a concentration >0.5 mg/mL may result in tissue cellulitis, fibrosis, necrosis, pain, edema, and erythema. Gastrointestinal toxicity: [US Boxed Warning]: Cisplatin can cause severe nausea and vomiting; use highly effective antiemetic premedication. WebMar 28, 2024 · Cisplatin is a chemotherapeutic drug that has been used in the treatment of various types of human cancers such as ovarian, lung, … flirt hair salon chandlerWebFeb 25, 2024 · Cisplatin is one of the most effective chemotherapy drugs for ovarian cancer, but resistance is common. The initial response to platinum‑based chemotherapy is as high as 80%, but in most advanced patients, final relapse and death are caused by acquired drug resistance. flirt halle abadi lyrics

"WebAim: To investigate the synergetic effect and the mechanism of antitumor action of the antibiotic lidamycin in combination with cisplatin in vitro. Methods: Cytotoxicity of the … " - Cisplatin pharmacology

Cisplatin pharmacology

WebCisplatin / pharmacology* Cisplatin / therapeutic use DNA / drug effects Drug Resistance / genetics Gene Expression Regulation, Neoplastic / drug effects Humans Organoplatinum Compounds / pharmacology ... WebApr 14, 2024 · Since HK-2-cells-generated-Abs, both by cisplatin or upon UV light exposure, can induce apoptosis in HK-2 cells, the purpose of this work was to study their metabolome and therein find the molecular features which help us to unravel the mechanisms of that phenomenon.

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WebCisplatin Injection is indicated as a single agent for patients with transitional cell bladder cancer which is no longer amenable to local treatments, such as surgery and/or … WebObjectives: Cisplatin-induced ototoxicity is a common permanent consequence of curative chemoradiation for locally advanced head and neck squamous cell carcinoma (HNSCC). Predictors of ototoxicity in HNSCC were examined. Materials and methods: In this prospective, observational cohort study, 206 adult HNSCC patients underwent …

WebCisplatin for injection has been administered at 75 mg/m. 2 . to 100 mg/m. intravenously per cycle once every 3 to 4 weeks on Day 1. Other doses and combination regimens have been used. 2.4 Advanced Bladder Cancer . Cisplatin for injection has been administered at 50 mg/m. 2 . to 70 mg/m. intravenously per cycle once every 3 to 4 weeks. WebApr 10, 2024 · Triple-negative breast cancer (TNBC) is one of the most aggressive forms of breast cancer and constitutes 10–20% of all breast cancer cases. Even though platinum-based drugs such as cisplatin and carboplatin are effective in TNBC patients, their toxicity and development of cancer drug resistance often hamper their clinical use. Hence, novel …

WebTherefore, the mechanism of cisplatin in promoting PD-L1 expression by YAP1 was investigated in the present study, and we found that cisplatin increased the expression level of YAP1 in the mouse liver with H22 cells. Meanwhile, cisplatin improved the expression level of PD-L1, IL-1β and CCL2 in the tumor microenvironment. WebThe results suggest that lidamycin enhancement of cisplatin-induced apoptosis associates with decrease of Bcl-2 protein expression, which may be useful for cancer chemotherapy.

WebAug 19, 2024 · Cisplatin is a platinum-based chemotherapeutic drug widely used in the treatment of various cancers such as testicular, ovarian, lung, bladder, and cervical cancers. However, its use and the dosage range applied have been limited by severe side effects (e.g., nephrotoxicity and ototoxicity) and by t …

WebSep 15, 2024 · Platinum-based anticancer drugs (PADs), mainly cisplatin, carboplatin, and oxaliplatin, are widely used efficacious long-standing anticancer agents for treating several cancer types. However, clinicians worry about PAD chemotherapy and its induction of severe non-targeted organ toxicity. Compelling evidence has shown that toxicity of PAD … great family vacations for familyWebFeb 16, 2024 · Warnings. Cisplatin can affect your nervous system, increase your risk of bleeding or infection, or harm your kidneys.. Call your doctor if you have a fever, mouth … great family vacations 2018 flirt hair salon fishersWebThe cardiotoxic effect of chemotherapeutic agents as cisplatin has become a major issue recently. Interference with mitochondrial dynamics, biogenesis, redox status, and apoptosis are the most possible underlying mechanisms. Semaglutide is a human glucagon-like peptide-1 receptor agonist (GLP-1R), w … great family vacations for adultsWebOct 5, 2014 · Cisplatin is clinically proven to combat different types of cancers including sarcomas, cancers of soft tissue, bones, muscles, and blood vessels. … great family vacations east coast usaWebSep 15, 2024 · Cisplatin is the prototype platinum coordination complex classified as an alkylating agent and used intravenously in the treatment of several forms of cancer. Cisplatin has been associated with a low rate of serum enzyme elevations and with rare cases of clinically apparent, acute liver injury. great family vacations for adult kidsWebCisplatin Pharmacology Cisplatin About Cisplatin Alkylating Agent, Platinum- Analog , Antineoplastic. Mechanism of Action of Cisplatin Cisplatin exerts its cytotoxic effect by … great family vacations in april