Cisplatin review

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August undefined, 2024

WebMar 13, 2024 · Cisplatin (cis-diamminedichloroplatinum II, CDDP) is one of the most effective chemotherapeutic agents. However, its clinical use is limited due to the severe side effects, including nephrotoxicity and acute kidney injury (AKI) which develop due to renal accumulation and biotransformation of CDDP. WebFeb 14, 2008 · Abstract. Cisplatin is a platinum chemotherapeutic used in a variety of malignancies. The antineoplastic activity occurs from DNA cross-links and adducts, in …

Cisplatin Intravenous Reviews and User Ratings: Effectiveness

WebCisplatin (DDP) is a common therapeutic option for non-small cell lung carcinoma (NSCLC). However, some patients fail to respond to the DDP chemotherapy. Therefore, identifying novel biomarkers to improve the diagnosis and treatment of NSCLC is important. WebFeb 1, 1989 · Background: Cisplatin is a major antineo- plastic drug for the treatment of solid tumors, but it has dose-dependent renal toxicity. Methods: We reviewed clinical and experimental literature on... phonic suffix

Association of the Epithelial–Mesenchymal Transition (EMT) with ...

WebJul 22, 2024 · Cisplatin-induced kidney toxicity is reviewed here. The use of cisplatin in patients with pre-existing kidney dysfunction and the kidney effects of the platinum … WebOct 5, 2014 · Cisplatin, cisplatinum, or cis-diamminedichloroplatinum (II), is a well-known chemotherapeutic drug. It has been used for treatment of numerous human cancers including bladder, head and neck, lung, ovarian, and testicular cancers. It is effective against various types of cancers, including carcinoma … phonic support

Side Effects of Cisplatin (Cisplatin Injection), Warnings, Uses - RxList

Reactive oxygen species in apoptosis induced by cisplatin: review …

WebThis review covered the hallmarks of inflammation common and distinct between different CITs, the role of innate immune components in development of CITs, as well as current … WebApr 24, 2024 · Cisplatin is a platinum-based alkylating compound that reacts with DNA to form interstrand cross-links and intrastrand bifunctional N-7 DNA adducts at d (GpG) and d (ApG) 3. Cisplatin is renally excreted and can accumulate in the renal proximal tubules, leading to nephrotoxicity. phonic starsWebSep 18, 2024 · Cisplatin is a medication used to manage and treat solid tumors and hematologic malignancies. It is in the alkylating agent class of cytotoxic medications. … how do you turn off iphone 13 pro

"WebApr 5, 2024 · Abstract. Cisplatin is a platinum containing drug first approved as an antineoplastic agent in 1978. It remains an important and effective therapy in many forms of cancer today. Cisplatin mediates its … " - Cisplatin review

Cisplatin review

Cisplatin (Intravenous Route) Side Effects - Mayo Clinic

WebSep 9, 2014 · Cisplatin is a common and effective cancer drug. It has revolutionized the treatment of advanced germ cell tumors which were previously considered highly fatal.1-3Side effects (including peripheral neuropathy) and acquired resistance unfortunately have limited its use4and paved the way for the development of new compounds. WebFeb 1, 2024 · drowsiness. feeling of fullness in the ears. fever or chills. increased thirst. loss of appetite. loss of balance. loss of hearing. lower back or side pain. nausea or vomiting.

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WebMost voted positive review. 39 People found this comment helpful . Stage three cancer at base of tongue. Now 45 months in remission. Received 62 radiation and 21 hrs of … WebSep 21, 2016 · Cisplatin produced superior response rates and survival in head and neck cancers. There are no published randomized phase III studies of bladder, cervical, endometrial, and esophageal cancers. CONCLUSION: Carboplatin does not possess equivalent activity to cisplatin in all platinum-sensitive tumors.

WebOct 23, 2003 · Cisplatin is a neutral inorganic, square planar complex that reacts with DNA to induce its characteristic biological effects, which culminate in either repair of the DNA damage and cell survival... WebCisplatin is a platinum-based agent whose nephrotoxicity is thought related to the chloride in the cis position. Cisplatin gains entry into tubular cells via uptake by the OCT-2 …

WebThe purpose of the review is to consolidate the reported risk of cardiotoxicity in patients treated with cisplatin based chemotherapy. Cisplatin can induce direct myocardial toxicity leading to atrial fibrillation whereas the potential of myocardial toxicity is amplified when the drug is administered in combination with other cardiotoxic agents. WebJun 3, 2024 · In the present review, we investigate the role of epithelial–mesenchymal transition (EMT) in the emergence of cisplatin (CP) resistance. CP is a key member of platinum compounds with excellent anti-tumor activity against different cancers such as breast cancer, prostate cancer, bladder cancer, lung cancer, brain tumors, and so on …

WebCisplatin is an effective chemotherapeutic agent for various solid tumours, but its use is limited by adverse effects in normal tissues. In particular, cisplatin is nephrotoxic and can cause acute kidney injury and chronic kidney disease. Preclinical studies have provided insights into the cellular …

WebSep 15, 2024 · SIDE EFFECTS. Nephrotoxicity - Dose-related and cumulative renal insufficiency is the major dose-limiting toxicity of cis-platin.Renal toxicity has been noted … how do you turn off inprivate browsingWebJul 1, 2024 · Abstract Cisplatin or (SP-4-2)-diamminedichloridoplatinum (II) is one of the most potential and widely used drugs for the treatment of various solid cancers such as … how do you turn off iphone x when frozenWebCisplatin or (SP-4-2)-diamminedichloridoplatinum(II) is one of the most potential and widely used drugs for the treatment of various solid cancers such as testicular, ovarian, head and neck, bladder, lung, cervical cancer, melanoma, lymphomas and several others. Cisplatin exerts anticancer activity … how do you turn off iphone xr manuallyWebOct 13, 2024 · In this Review, we provide an overview of the mechanisms that underlie cisplatin-induced AKI and CKD and discuss the therapeutic implications of potential … phonic summit mixerWebCisplatin is a chemotherapy drug which is used to treat cancers including: sarcoma, small cell lung cancer, germ cell tumors, lymphoma, and ovarian cancer. While it is often … how do you turn off iphone 13 miniWebAug 1, 2007 · Cisplatin is a major antineoplastic drug used for the treatment of solid tumors. Its chief dose-limiting side effect is nephrotoxicity; 20% of patients receiving high-dose cisplatin have severe renal dysfunction. Cisplatin-DNA crosslinks cause cytotoxic lesions in tumors and other dividing cells. phonic t8100 tube vocalmaxWebThis study investigated non-targeted metabolomic analysis on ABs and medium from apoptotic HK-2 cells induced with cisplatin or exposure to UV light. These results … how do you turn off iphone xs if its frozen