Potassium oxonate induced hyperuricemia

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August undefined, 2024

Web22 Jul 2024 · A hyperuricemia mouse model was established by potassium oxonate (PO) and adenine for 21 days. Ultra Performance Liquid Chromatography was used to … Web11 Nov 2024 · This study was aimed to evaluate the effect of astaxanthin (ASX) on hyperuricemia and kidney inflammation in potassium oxonate (PO) and hypoxanthine …

Renal herb formula protects against hyperuricemic nephropathy …

Webpotassium oxonate-induced hyperuricemia. Screening of the extract for its XO inhibitory activity followed by their potential to reduce serum uric acid levels and XO activity may play an important role in identifying a potent chemical entity for the treatment of gout and related inflammatory disorders. To WebAll of these efforts resulted in the identification of compound 8, a potent XO inhibitor (IC50 = 48.6 nM) with novel 2-phenylthiazole-4-carboxylic acid scaffold. Moreover, lead compound 8 exhibited hypouricemic effect in potassium oxonate-hypoxanthine-induced hyperuricemic mice. chat online citizens advice

Astaxanthin attenuated hyperuricemia and kidney inflammation by …

Web8 Apr 2024 · Renal herb formula (RHF) inhibited apoptosis in the kidney of mice with potassium oxonate-induced hyperuricemic nephropathy, as indicated by western blot analysis of Bcl2, Bax, p-p53, c-Cas-9, and c-Cas-3 (A-G) and immunofluorescent staining of p-p53 (H). ... RIP3-deficience attenuates potassium oxonate-induced hyperuricemia and … Web24 Mar 2024 · Hyperuricemia is a metabolic disease caused by abnormalities in purine metabolism, mainly due to the increased formation or reduced excretion of urate. Approximately two-thirds of the urate produced in humans is excreted by the kidneys. Urate undergoes extensive filtration, reabsorption and secretion in the renal proximal tubule ( … Hyperuricemia is a metabolic disorder characterized by an excessively increased serum urate concentration, which may occur due to overproduction and/or insufficient intestinal excretion and/or urate underexcretion … See more The datasets analyzed in this article are publicly available. The RNA-seq data presented in the study are deposited in the public repository with GEO accession number GSE186871 or SRA accession number SRP343909. … See more In recent years, the prevalence of hyperuricemia has increased, and more and more young people are suffering from this disease (Yong et al., 2024). Febuxostat is more … See more customized crewneck sweatshirts

Polydatin attenuates potassium oxonate-induced hyperuricemia …

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Web10 Feb 2024 · Group 2; positive hyperuricemic group (HU), received potassium oxonate (PO) intraperitoneally (250 mg/kg bw, once a day at 8:00 am). The dosages of PO and timing were determined as stated above [ 19 ]. Time of administration was fixed to avoid noctorinal and diurnal changes in biochemical measurements. Web15 Jan 2015 · Nuciferine, a major aporphine alkaloid of the leaves of Nelumbo nucifera, was found to decrease serum urate levels and improved kidney function, as well as inhibited … customized crocsWeb5 Dec 2024 · Berberrubine attenuates potassium oxonate- and hypoxanthine-induced hyperuricemia by regulating urate transporters and JAK2/STAT3 signaling pathway - … customized croc charms

"Web24 Apr 2024 · Recently, MOL was reported to possess antioxidant, anti-dyslipidemia and hepato-renal protective activities, indicating that MOL could become a potential agent to … " - Potassium oxonate induced hyperuricemia

Potassium oxonate induced hyperuricemia

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Web22 Nov 2024 · Hyperuricemia was induced by oral administration of potassium oxonate (PO) and hypoxanthine to mice for 7 days. The biochemical index results showed that treatments with low, medium, and high doses of IRh (50, 100, and 150 mg kg −1) significantly reduced serum UA levels and inhibited XOD activity in serum and in the liver. Web1 Oct 2024 · Based on this, in the present study, we established a hyperuricemia model induced by potassium oxonate (PO) (300 mg/kg), which has been reported to cause …

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Web8 Apr 2024 · Renal herb formula (RHF) inhibited apoptosis in the kidney of mice with potassium oxonate-induced hyperuricemic nephropathy, as indicated by western blot … Web12 Sep 2024 · Cellular cytoplasmic xanthine oxidase (XO)–mediated uric acid synthesis and extracellular excess uric acid exposure are both causes of cardiomyocytic injury under the …

Web5 Aug 2024 · Potassium oxonate induced acute HUA in tree shrews at lower doses compared with other animal models. Potassium oxonate-treated tree shrews may be a … Web15 Nov 2024 · We used potassium oxonate (PO) to induce HC in male SD rats and then treated them with L. plantarum TCI227 in a dose-dependent manner (HC + LD, HC + MD, HC + HD) for 4 weeks. We examined organ weight, conducted biochemical examinations of blood and urine, and analyzed the intestinal microbiota in feces through a 16s rDNA …

Web12 Sep 2024 · Potassium oxonate suppresses uric acid degradation to increase extracellular concentration, while hypoxanthine is the catalytic substrate of XO. We aimed to observe cardiac damage in a chronic HUA mouse model induced by … Web5 Dec 2024 · Berberrubine attenuates potassium oxonate- and hypoxanthine-induced hyperuricemia by regulating urate transporters and JAK2/STAT3 signaling pathway …

WebThe results indicated that SSO treatment prominently inhibited the increase of serum uric acid (UA), creatinine (CRE), and urea nitrogen (BUN) levels and hepatic xanthine oxidase …

Web18 Dec 2024 · Our results demonstrated that RDP1 (the minimum effective concentration is 10 μg/kg) could significantly reduce the serum uric acid and creatinine and alleviate … chat online da timWebPolydatin attenuates potassium oxonate-induced hyperuricemia and kidney inflammation by inhibiting NF-κB/NLRP3 inflammasome activation via the AMPK/SIRT1 pathway Lvyi Chen *a and Zhou Lan b Author affiliations Abstract This study was designed to investigate the effects of polydatin (PLD) on potassium oxonate-induced hyperuricemic rats. customized crochet hook wholesaleWeb8 Jan 2024 · Potassium oxonate-induced hyperuricemic mice are appropriate experimental models for investigating the mechanism underlying hyperuricemia and for developing therapeutic agents. Allopurinol (AP) is an anti-hyperuricemic agent that acts by reducing XOD activity and serum UA levels. chat online eduzz chat online datingWeb13 Aug 2024 · Hyperuricemia is the primary cause of gouty arthritis and other metabolic disorders. Eggshell membrane (EM) is an effective and safe supplement for curing pain and stiffness connected with osteoarthritis. However, the effect of EM on hyperuricemia is unclear. This study determines the effects of EM on potassium oxonate-injected … customized crochet headbandsWebCurcumin (CUR), a natural polyphenol component extracted from the rhizome of Curcuma longa, has been reported to treat various symptoms such inflammation disease, seems to … customized crocs charmsWebPotassium oxonate-treated mice showed significantly high mRNA levels of ATP-binding cassette, subfamily G, membrane 2 (ABCG2), organic anion transporter 1 (OAT1), OAT3, … chat online con video